The Science
Revolutionary sleep technology powered by nature's deepest intelligence. Discover how Pistachion® Complex transforms your relationship with rest.
Explore the ScienceBeyond Melatonin: The Full Sleep Axis Solution
While synthetic melatonin targets only the pineal gland, PistachDream restores balance to the entire Sleep Axis—gut, brain, and hormonal systems—gently guiding your body into a state of natural rest.
Supports the Full Sleep Axis
Not just the pineal gland—PistachDream supports your gut-brain-hormone connection to calm the stress response, rebalance rhythms, and naturally induce rest.
Pistachio Phyto-Melatonin + Plant Extracts
Featuring a clinically inspired blend of plant-based actives—including Pistachio Phyto-Melatonin—to support neurotransmitters, microbiota, and hormonal harmony.
Harmony, Not Sedation
Rather than force sedation, PistachDream tunes your body's internal symphony—restoring the rhythm of natural sleep through biological alignment.
Core Technologies
PhytoDreamSync™
Deep circadian rhythm alignment through plant-based compounds that work with your body's natural clock.
✓ Gentle, plant-based alignment
✓ No synthetic hormone disruption
✓ Supports natural rhythms
BioMelanoCore™
A botanical melatonin nucleus with neural repair elements, providing comprehensive sleep support.
✓ Bioidentical to human melatonin
✓ Neural repair activation
✓ Enhanced bioavailability
Gummy-Mouth Matrix™
Proprietary delivery system for enhanced sublingual absorption, bypassing the gut for faster onset.
✓ Sublingual & buccal absorption
✓ Faster onset time
✓ Maximum bioavailability
Powered by Pistachion® Complex
Each microdose is extracted from the essence of over 200 pistachios—delivering next-gen plant intelligence with Nighttime Antioxidants for cellular restoration activated during sleep.
How It Works: The Complete Process
Experience the gentle progression from taking your gummy to deep, restorative sleep through our four-stage process.
1. Rapid Absorption
Gummy-Mouth Matrix™ Technology delivers compounds directly through oral tissues for fast onset and maximum bioavailability.
15-30 minutes: Enhanced sublingual and buccal absorption bypasses the gut for immediate effect.
2. Natural Integration
Bioidentical plant melatonin integrates seamlessly with your body's existing systems, supporting the full Sleep Axis.
30-45 minutes: PhytoDreamSync™ aligns with your circadian rhythm without hormonal disruption.
3. Sustained Release
Plant matrix provides gradual release throughout the night for consistent sleep quality and deep restoration.
Throughout the night: BioMelanoCore™ activates neural repair and antioxidant defense systems.
4. Morning Restoration
Wake up refreshed without grogginess, with enhanced cellular repair from overnight antioxidant activity.
Morning: Natural awakening with improved cognitive function and cellular restoration.
Clinical Benefits & Research
Backed by scientific research, PistachDream delivers measurable improvements in sleep quality, anti-inflammatory support, and longevity benefits.
🔥 Anti-Inflammatory Power
6.5x stronger COX-2 inhibition than synthetic melatonin
Powerful anti-inflammatory support for whole-body wellness
⚡ Superior Antioxidant Defense
Up to 470% greater free radical scavenging
Advanced antioxidant defense for cellular protection
🧬 Longevity Support
Enhances NAD+ levels and activates SIRT1
Critical for DNA repair and healthy aging processes
🧠 Cognitive Enhancement
Mitochondrial protection and memory-supportive metabolites
Supports brain health and cognitive function
🌿 Natural Safety
No synthetic side effects or morning grogginess
Gentle on your system with natural metabolites
🔄 Circadian Support
Supports natural circadian rhythms without hormonal disruption
Long-term effectiveness without tolerance buildup
Scientific References
Pistachio Melatonin Content Research
[1] Labani, N., et al. (2023). Pistacia vera Extract Potentiates the Effect of Melatonin on Human Melatonin MT1 and MT2 Receptors with Functional Selectivity. Pharmaceutics, 15(7), 1845.
High endogenous melatonin content in pistachio extract (5.28 ± 0.46 mg/g extract) with potent effects on melatonin receptors.
[2] Losso, J.N. & Yeboah-Awudzi, M. (2018). Melatonin Contents of Raw and Roasted American Pistachios. Louisiana State University Study.
American pistachios contain approximately 660 nanograms of melatonin per gram, higher than most other foods.
[3] Ghasemnezhad, M. & Honermeier, B. (2014). Spectrofluorimetric determination of melatonin in Pistacia species. Spectrochimica Acta A, 132, 326–329.
Method development for measuring and comparing melatonin content in different Pistacia varieties.
Phytomelatonin Superiority Research
[4] Kukula-Koch, W., et al. (2021). Is Phytomelatonin Complex Better Than Synthetic Melatonin? The Assessment of the Antiradical and Anti-Inflammatory Properties. Molecules, 26(19), 6087.
Key Finding: Phytomelatonin showed 6.5x stronger COX-2 inhibition and 267-470% greater free radical scavenging than synthetic melatonin.
[5] Phytomelatonin.org Research Summary (2021). Comparative Analysis of Phytomelatonin vs Synthetic Melatonin. Antioxidant Research Institute.
Comprehensive comparison showing superior bioavailability and efficacy of plant-based melatonin compounds.
Plant Melatonin Research
[6] Arnao, M.B. & Hernández-Ruiz, J. (2018). Phytomelatonin: A new perspective in plant physiology. Trends in Plant Science, 23(10), 834–841.
Comprehensive review highlighting melatonin presence in edible plants and its potential as a nutraceutical.
[7] Hardeland, R. (2016). Melatonin in plants: diversity of levels and multiplicity of functions. Frontiers in Plant Science, 7, 198.
Pistachios show exceptionally high melatonin levels compared to other plants, with detailed analysis of plant melatonin functions.
[8] Reiter, R.J., et al. (2007). Melatonin in edible plants identified by radioimmunoassay and by high performance liquid chromatography-mass spectrometry. World Review of Nutrition and Dietetics, 97, 211–230.
Foundational study on presence, biodisponibility and function of plant melatonin in foods including pistachios.
[9] Arnao, M.B. & Hernández-Ruiz, J. (2018). Melatonin and its relationship to plant hormones. Annals of Botany, 121(2), 195–207.
Explores regulatory role of phytomelatonin in synergy with plant hormones like auxins and ethylene.
Supporting Clinical Research
[10] Melatonin Metabolites Research. N1-Acetyl-5-methoxykynuramine and cognitive enhancement. Neurological Sciences Review.
Research on melatonin metabolites supporting memory and cognitive function through mitochondrial protection.
[11] Meng, X., et al. (2017). Dietary Sources and Bioactivities of Melatonin. Nutrients, 9(4), 367.
Comprehensive review of food sources of melatonin and their biological activities in human health.
[12] Howatson, G., et al. (2012). Effect of tart cherry juice on melatonin levels and enhanced sleep quality. European Journal of Nutrition, 51(8), 909-916.
Comparative study showing natural food sources of melatonin can effectively improve sleep quality and duration.